Download Actin-based Motility: Cellular, Molecular and Physical by J. Victor Small, Klemens Rottner (auth.), Marie-France PDF

By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)

This e-book offers the mobile, molecular and actual facets of strength and circulation through the self-assembly of actin, the most ample proteins present in cells, into cytoskeletal filaments. « Actin-based motile procedures » are answerable for a wide number of motile actions similar to chemotactic locomotion, embryonic and metastatic mobilephone migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic tactics together with, axis patterning in early embryos, axonal development in mind improvement, and the immune reaction and synaptic plasticity tactics on the foundation of studying and reminiscence. The e-book describes how the lately undertaken multidisciplinary and multiscale methods have explored the molecular and actual mechanisms on the beginning of strength and move produced by means of actin self-assembly. the selected subject matters convey how advances were made within the box of telephone motility end result of the growth in dwell cellphone imaging, gentle microscopy, better solution within the constitution of huge protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the improvement of nanotechnologies permitting us to degree forces within the diversity of pico- to nano-newtons produced by means of actin assemblies.

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However, it has been unclear how these characteristic structures are formed by the dynamic collaboration between the actin cytoskeleton and the plasma membrane. Recently, increasing numbers of membrane-deforming proteins connecting the actin cytoskeleton and the plasma membrane have been found. These proteins contain the BAR, EFC/F-BAR and IMD/I-BAR domains, which not only deform membranes but also bind to N-WASP/WAVE proteins. 1). 2 A Variety of Plasma Membrane Invaginations The clathrin-coated pit (CCP) is one of the most well characterized membrane invaginations at the plasma membrane.

M. Knipe. 1973. Functions of cytoplasmic fibers in nonmuscle cell motility. In Cold Spring Harbor Symposium on Quantitative Biology. Cold Spring Harbor Laboratory, Cold Spring Harbor. 523–34. D. Welch. 2006. The ARP2/3 complex: an actin nucleator comes of age. Nat Rev Mol Cell Biol. 7:713–26. J. Eck. 2007. Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem. 76:593–627. , A. Sechi, S. V. Small. 2001. Scar/WAVE is localised at the tips of protruding lamellipodia in living cells.

Nature. 272:638–39. P. Resch. 2005. The comings and goings of actin: coupling protrusion and retraction in cell motility. Curr Opin Cell Biol. 17:517–23. , G. Rinnerthaler, and H. Hinssen. 1982. Organization of actin meshworks in cultured cells: the leading edge. Cold Spring Harb Symp Quant Biol. 46 Pt 2:599–611. , K. Rottner, I. I. Anderson. 1998. Assembling an actin cytoskeleton for cell attachment and movement. Biochim Biophys Acta. 1404:271–81. , T. Stradal, E. Vignal, and K. Rottner. 2002.

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