By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
File from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental experiences and Toxicology. quantity 2. Softcover.
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2
He began coughing upon exposure to phosgene and experienced dyspnea and chest tightness within 30 min. Four hours after exposure, he was hospitalized with hypotension, tachycardia, tachypnea, cyanosis, and pulmonary edema. The patient was intubated and administered dopamine and methylprednisolone. From the second to the sixth day of hospitalization, he developed mediastinal and subcutaneous emphysema, bilateral pneumohydrothoraces, elevated white blood cell counts, fever, and hemiparesis on the right side.
0 ppm as the lowest concentration at which the distinctive “new-mown hay” odor of phosgene could be detected. 1). Nonlethal information synthesized from this review is presented in Table 1–4. From the above data and from animal data for “initial lung damage,” Diller and Zante (1982) synthesized information for nonlethal effects of phosgene in humans (Table 1–5). 1. Case Reports A 30-y-old male was occupationally exposed to phosgene at an unknown concentration (Stavrakis 1971). After a short episode of coughing, he returned to work and completed the final 3 h of his shift.
3. Guinea Pigs The few acute lethality studies of phosgene in guinea pigs do not contain experimental details such as strain or gender, number of animals exposed, or analytical methodology. These less-than-adequate studies are summarized in Table 1–8. 4. Rabbits As was the case with guinea pigs, the few acute lethality studies of phosgene in rabbits do not contain experimental details such as strain or gender, number of animals exposed, or analytical methodology. These less than adequate studies are summarized in Table 1–9.
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