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By C. Meyers

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166–169 HHV-8 has been shown to have certain genes to be homologous to cyclin D1 and G-protein coupled receptors, which are known to contribute to oncogenesis. 150,170,171 HIV PATHOGENESIS IN KS The HIV virus itself may be an oncogene in KS development. A regulatory protein of HIV released by infected cells, called the Tat protein, guards KS cells from apoptosis,172 stimulates growth and angiogenesis,173,174 and also increases the production and release of matrix metalloproteinases (MMPs) from endothelial and inflammatory cells.

001). 012). In addition,The Swiss cohort study76 with 6,636 HIV-infected individuals found the incidence of systemic NHL post-HAART to be 4 cases/1,000 p-y. 2. AIDS Malignancies 29 However, other studies found nonsignificant increases in AIDS-related NHL incidence. 2). 5 cases/1,000 p-y post-HAART (p-value not significant). 86,87 The IPI includes clinical features that reflect the growth and invasive potential of the tumor (tumor stage, serum LDH level, and number of extranodal disease sites), the patient’s response to the tumor (performance status), and the patient’s ability to tolerate Table 3.

The simplified model for younger patients (the age-adjusted IPI) uses a subgroup of these clinical features (tumor stage, LDH level, and performance status). 88 compared the prognostic factors for survival and the use of the IPI in pre- and post-HAART HIV-infected individuals with diffuse-large cell lymphoma. In groups with low-, low-intermediate-, and high-intermediate-risk IPI disease, 3-year overall survival rates were 20%, 22%, and 5% in the pre-HAART era and 64%, 64%, and 50% in the HAART era, respectively.

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